From the vaccine vial against the SARS-CoV-2 coronavirus, one more dose or even two doses can be obtained, but only a special syringe/needle with “low dead volume” can be used to extract the drug with extremely high precision Precise amount.
In recent months, Vaccination campaign Against this Coronavirus SARS-CoV-2, The doctors and nurses involved in the management realized Vial God Coronavirus disease vaccine Compared with drugs “certified” by regulatory agencies, other doses of drugs can be extracted. For example, from BNT162b2 / Tozinameran (Suitability) Developed by Pfizer Partnership with Biological Technology Compared with the 5 doses indicated in the Summary of Product Characteristics (SPC), 6 or even 7 doses can be obtained.Given this additional availability and Chronic deficiency Dosage, Human Medicines Committee (Coronary Heart DiseaseEuropean Medicines Agency ()EMA) Soon it was announced not only the update of the actual available dose of the vial, but also the authorization to use. Without the approval of the competent authority, the sixth or even seventh dose will be “Unlawful“This may cause problems for doctors who are engaged in vaccination work.
But there is a “logistics” problem with extracting the extra dose, which is related to syringe.The larger 3ml standard solution is not precise enough to extract an additional dose from the vial, but you need to use a syringe and/or needle in combination Low dead volume, Explain EMA, The dead volume must not exceed 35 microfat.The most suitable syringe for this purpose is 1 mlThin, able to hold less liquid between the plunger and the needle tip.This Low dead volume syringe They have a specific plunger that reaches the needle to eliminate most of the remaining liquid. As Dr. Daniel Griffin, a doctor at the New York Presbyterian Hospital and head of a series of vaccination centers, pointed out, it is quite complicated to use a large 3 ml syringe to get the exact dose from a medicine bottle, but there is indeed waste. Risks are very precious doses.
In Germany, if there are no special regulations for additional doses, doctors should bear personal and criminal responsibility for these additional vaccinations. Therefore, due to this reason and the lack of sufficient syringes (for example, Tell Der Spiegel Written by Jenny May, Director of Logistics at the Thuringia Vaccination Center. However, this is not the case everywhere. Some federal states, such as the Rhineland-Palatinate state, have clearly expressed their support for each available dose. “In view of the continuing shortage of pandemic vaccines, the Rhineland-Palatinate Ministry of Health recommends that if additional vaccines can be taken completely without particles, the seventh dose of Comirnaty (Pfizer vaccine) or the eleventh Vaxzevria ( AstraZeneca vaccine),” a local politician told Der Spiegel. In Italy, the Technical and Scientific Committee (Cts) of the Italian Medicines Agency (AIFA) pointed out that it is necessary to try to get as many doses as possible from each vial; as shown, Pfizer vaccine vials can reach up to 6/7, Pfizer Vaccine vials up to 12 Hyundai NIAID E AstraZeneca-Oxford-IRBM (Start with 10 doses).
Come Designated by AIFA After “discovering” an additional dose of Pfizer, if the amount of vaccine remaining in the vial after the fifth injection cannot provide the full dose 0.3 ml, “The medical staff must discard the vial and its contents.”Indeed Mixing is strictly prohibited The leftovers in the funds from different medicine bottles to obtain the full dose, for example Risk of contamination. AIFA also added that any unused vaccine “must be discarded within 6 hours of dilution.” To avoid this waste, precision syringes with low dead volume are essential, but as Dr. May of Spiegel explained, they are not always available. In some cases, kits containing vaccines will come with “inaccurate” 3 mm syringes. Considering the “extra” inoculations that can be obtained with these medical devices, the practical value of these medical devices is actually as valuable as the entire batch of doses.