He is discussing the proposal of the German Minister of Health to shorten the vaccination cycle to avoid adverse effects on the vaccination campaign during the summer holidays. As shown by the vaccine data, a “practical” solution, but at the cost of efficacy.
Vaccination campaign AstraZeneca, Has been blocked by indecision and fear related to news related to side effects, risks may be further penalized summer vacation. There is a 12-week interval between the first and second injections, and anyone who receives the Anglo-Swedish serum injection for the first time today will receive a booster injection in early August (maybe during vacation). This situation may reduce the attractiveness of the AstraZeneca vaccine, prompting people to postpone vaccination or choose (where possible) a different anti-Covid vaccine, booster vaccination at six weeks (such as Pfizer and Moderna), or One dose of vaccination. Johnson & Johnson.
In Germany, a problem has arisen and is discussing the proposal of Health Minister Jens Spahn. This hypothesis puts forward the hypothesis that the interval between two doses of AstraZeneca should be shortened to four weeks. A “practical” solution, but according to the latest data from the University of Oxford, Damage effect.
Extending the recall time-originally decided in the UK to provide protection in a single dose to as many people as possible-has actually proven to be a way to maximize the protection given by the AstraZeneca vaccine, and it also brings Other countries/regions, including Italy, have also postponed the time for the second medication.
The impact of the recall interval is described in detail in the study published in Lancet, They said 81% protection When the second dose was taken at least 12 weeks after the first dose, it was 55% when the interval between the second doses was less than six weeks. At the same time, the 12-week interval also had an impact on the antibody response, resulting in “After an interval of twelve weeks or more, it is more than twice as high as the interval of less than six weeks“Read research.
In general, when administered 12 weeks apart between the two doses, the vaccine generally showed higher efficacy and produced higher antibodies. “This indicates that there is a correlation between humoral immune response (mediated by antibodies, ed) and efficacy.Researchers from the University of Oxford pointed out that the use of other adenovirus-based vaccines (such as vaccines against influenza and Ebola virus disease) can also observe greater protection associated with a stronger immune response after the dose interval is extended. “Compared to procedures with shorter intervals, procedures with a 3-month interval may have advantages, allowing you to protect as many people as possible as quickly as possible, and Also improve protection After receiving the second dose.