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Where once were black boxes, a new statistical tool illuminates

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Where once were black boxes, a new statistical tool illuminates

Where once were black boxes, NIST's new LANTERN illuminates
How do you figure out how to alter a gene so that it makes a usefully different protein? The job might be imagined as interacting with a complex machine (at left) that sports a vast control panel filled with thousands of unlabeled switches, which all affect the device’s output somehow. A new tool called LANTERN figures out which sets of switches—rungs on the gene’s DNA ladder—have the largest effect on a given attribute of the protein. It also summarizes how the user can tweak that attribute to achieve a desired effect, essentially transmuting the many switches on our machine’s panel into another machine (at right) with just a few simple dials. Credit: B. Hayes / NIST

Researchers at the National Institute of Standards and Technology (NIST) have developed a new statistical tool that they have used to predict protein function. Not only could it help with the difficult job of altering proteins in practically useful ways, but it also works by methods that are fully interpretable—an advantage over the conventional artificial intelligence (AI) that has aided with protein engineering in the past.

The new tool, called LANTERN, could prove useful in work ranging from producing biofuels to improving crops to developing new disease treatments. Proteins, as building blocks of biology, are a key element in all these tasks. But while it is comparatively easy to make changes to the strand of DNA that serves as the blueprint for a given protein, it remains challenging to determine which specific base pairs—rungs on the DNA ladder—are the keys to producing a desired effect. Finding these keys has been the purview of AI built of deep neural networks (DNNs), which, though effective, are notoriously opaque to human understanding.

Described in a new paper published in the Proceedings of the National Academy of Sciences, LANTERN shows the ability to predict the genetic edits needed to create useful differences in three different proteins. One is the spike-shaped protein from the surface of the SARS-CoV-2 virus that causes COVID-19; understanding how changes in the DNA can alter this spike protein might help epidemiologists predict the future of the pandemic. The other two are well-known lab workhorses: the LacI protein from the E. coli bacterium and the green fluorescent protein (GFP) used as a marker in biology experiments. Selecting these three subjects allowed the NIST team to show not only that their tool works, but also that its results are interpretable—an important characteristic for industry, which needs predictive methods that help with understanding of the underlying system.

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“We have an approach that is fully interpretable and that also has no loss in predictive power,” said Peter Tonner, a statistician and computational biologist at NIST and LANTERN’s main developer. “There’s a widespread assumption that if you want one of those things you can’t have the other. We’ve shown that sometimes, you can have both.”

The problem the NIST team is tackling might be imagined as interacting with a complex machine that sports a vast control panel filled with thousands of unlabeled switches: The device is a gene, a strand of DNA that encodes a protein; the switches are base pairs on the strand. The switches all affect the device’s output somehow. If your job is to make the machine work differently in a specific way, which switches should you flip?

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Because the answer might require changes to multiple base pairs, scientists have to flip some combination of them, measure the result, then choose a new combination and measure again. The number of permutations is daunting.

“The number of potential combinations can be greater than the number of atoms in the universe,” Tonner said. “You could never measure all the possibilities. It’s a ridiculously large number.”

Because of the sheer quantity of data involved, DNNs have been tasked with sorting through a sampling of data and predicting which base pairs need to be flipped. At this, they have proved successful—as long as you don’t ask for an explanation of how they get their answers. They are often described as “black boxes” because their inner workings are inscrutable.

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“It is really difficult to understand how DNNs make their predictions,” said NIST physicist David Ross, one of the paper’s co-authors. “And that’s a big problem if you want to use those predictions to engineer something new.”

LANTERN, on the other hand, is explicitly designed to be understandable. Part of its explainability stems from its use of interpretable parameters to represent the data it analyzes. Rather than allowing the number of these parameters to grow extraordinarily large and often inscrutable, as is the case with DNNs, each parameter in LANTERN’s calculations has a purpose that is meant to be intuitive, helping users understand what these parameters mean and how they influence LANTERN’s predictions.

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The LANTERN model represents protein mutations using vectors, widely used mathematical tools often portrayed visually as arrows. Each arrow has two properties: Its direction implies the effect of the mutation, while its length represents how strong that effect is. When two proteins have vectors that point in the same direction, LANTERN indicates that the proteins have similar function.

These vectors’ directions often map onto biological mechanisms. For example, LANTERN learned a direction associated with protein folding in all three of the datasets the team studied. (Folding plays a critical role in how a protein functions, so identifying this factor across datasets was an indication that the model functions as intended.) When making predictions, LANTERN just adds these vectors together—a method that users can trace when examining its predictions.

Other labs had already used DNNs to make predictions about what switch-flips would make useful changes to the three subject proteins, so the NIST team decided to pit LANTERN against the DNNs’ results. The new approach was not merely good enough; according to the team, it achieves a new state of the art in predictive accuracy for this type of problem.

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“LANTERN equaled or outperformed nearly all alternative approaches with respect to prediction accuracy,” Tonner said. “It outperforms all other approaches in predicting changes to LacI, and it has comparable predictive accuracy for GFP for all except one. For SARS-CoV-2, it has higher predictive accuracy than all alternatives other than one type of DNN, which matched LANTERN’s accuracy but didn’t beat it.”

LANTERN figures out which sets of switches have the largest effect on a given attribute of the protein—its folding stability, for example—and summarizes how the user can tweak that attribute to achieve a desired effect. In a way, LANTERN transmutes the many switches on our machine’s panel into a few simple dials.

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“It reduces thousands of switches to maybe five little dials you can turn,” Ross said. “It tells you the first dial will have a big effect, the second will have a different effect but smaller, the third even smaller, and so on. So as an engineer it tells me I can focus on the first and second dial to get the outcome I need. LANTERN lays all this out for me, and it’s incredibly helpful.”

Rajmonda Caceres, a scientist at MIT’s Lincoln Laboratory who is familiar with the method behind LANTERN, said she values the tool’s interpretability.

“There are not a lot of AI methods applied to biology applications where they explicitly design for interpretability,” said Caceres, who is not affiliated with the NIST study. “When biologists see the results, they can see what mutation is contributing to the change in the protein. This level of interpretation allows for more interdisciplinary research, because biologists can understand how the algorithm is learning and they can generate further insights about the biological system under study.”

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Tonner said that while he is pleased with the results, LANTERN is not a panacea for AI’s explainability problem. Exploring alternatives to DNNs more widely would benefit the entire effort to create explainable, trustworthy AI, he said.

“In the context of predicting genetic effects on protein function, LANTERN is the first example of something that rivals DNNs in predictive power while still being fully interpretable,” Tonner said. “It provides a specific solution to a specific problem. We hope that it might apply to others, and that this work inspires the development of new interpretable approaches. We don’t want predictive AI to remain a black box.”



More information:
Peter D. Tonner et al, Interpretable modeling of genotype–phenotype landscapes with state-of-the-art predictive power, Proceedings of the National Academy of Sciences (2022). DOI: 10.1073/pnas.2114021119

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Where once were black boxes, a new statistical tool illuminates (2022, June 22)
retrieved 23 June 2022
from https://phys.org/news/2022-06-black-statistical-tool-illuminates.html

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This 10-second test could measure your risk of death, study says

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This 10-second test could measure your risk of death, study says

Scientists may have found a way to measure your risk of death. A new study published in the British Journal of Sports Medicine posits that a 10-second balance test could help measure your overall risk of dying.

A 10-second test may be able to measure your risk of death

woman training balance
Balance can play a key part in your overall health. Image source: Amazon

The study was conducted by several scientists using a pool of 1,702 people aged between 51 to 75 years. They examined data about the participants taken between 2008 and 2020 and measured how well they could perform a 10-second one-legged balance test. The results, they say, could allow doctors to better measure your risk of death.

The 10-second test requires the participant to stand on one leg, with the free leg resting on the back of the standing leg. They then place their hands at their side and try to stay still. During the study, the participants were given three chances to complete the balance test. Around 20 percent were unable to complete the test. The number of people unable to complete it also increased with age.

Five percent of participants between 51 and 55 failed, while 8 percent between 56 and 60 failed. From there, 18 percent of people aged 61 to 65 failed, and then 37 percent of those 66 to 70 years of age failed. Finally, 54 percent of people between 71 and 75 years of age failed the test to measure their risk of death.

Measuring mortality

Doctor in a face mask with microscopeImage source: JHDT Productions/Adobe

The researchers found that most who failed the balance test tended to have higher body weights, or suffered from cardiovascular disease, type-2 diabetes, or high cholesterol. Additionally, after they adjusted the findings for age, sex, and existing health conditions, the scientists believe those who failed had an 84 percent increased risk of death over the next seven years.

But how does it work? These findings are intriguing, to say the least. However, it is important to look at the wider picture that the doctors were painting here. This balance test may be able to measure your risk of death. However, it isn’t a way to prevent heart disease, diabetes, or any other diseases. It’s simply an “all-cause mortality” test.

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Balance is an important aspect of our body. And many doctors believe that balance can be a good indicator of how healthy a person is. Since the test only takes 10 seconds to complete it isn’t a bad way to measure the possible risk of death. However, it also isn’t going to tell you any in-depth information about your risk of any diseases or other issues.

As such, the researchers are pushing for the balance test to be added to regular doctor visits. Alongside the other tests we run, it could increase the chance of catching diseases or issues before they advance. There are, of course, other things you can do to reduce your risk of death, like watching less TV each day.

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What to watch on Peacock: New movies and shows in July 2022

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What to watch on Peacock: New movies and shows in July 2022

If you’re looking for any new originals to watch on Peacock in July 2022, you’ve got a few intriguing options. At the top of the list is a new dark comedy called The Resort, created by Andy Siara (Palm Springs) and starring William Jackson Harper (The Good Place) and Cristin Milioti (Palm Springs). Other highlights include Trigger Point, Hart to Heart, and Love Island. There will also be new The Office: Superfan Episodes in July.

You can watch some shows on Peacock for free on sign up for Premium right here.

New releases on Peacock coming in July 2022

Streaming July 1

  • Armageddon, 1998
  • American Pie, 1999
  • American Pie 2, 2001
  • American Reunion, 2012
  • American Wedding, 2003
  • Antz, 1998*
  • Away We Go, 2009
  • The Bad Guys, 2022*
  • Batman, 1989
  • Batman & Robin, 1997
  • Batman Forever, 1995
  • Batman Returns, 1992
  • The Big Lebowski, 1998
  • The Big Wedding, 2013*
  • Blue Crush, 2002
  • Blue Crush 2, 2011
  • Blue Valentine, 2011*
  • Born On The Fourth of July, 1989
  • Bridesmaids, 2011*
  • Bring It On Again, 2004
  • Bring It On: All or Nothing, 2006
  • Bulletproof, 1996
  • Cast Away, 2000
  • The Change-Up, 2011
  • Cowboys & Aliens, 2011
  • Crimson Tide, 1995
  • Date Night, 2010
  • Dazed and Confused, 1993
  • Dodgeball: A True Underdog Story, 2004
  • End Of The Line: The Women of Standing Rock, 2004
  • Eternal Sunshine of the Spotless Mind, 2004
  • Gnomeo & Juliet, 2011
  • Fantastic Four, 2005
  • Field of Dreams, 2005*
  • For Love of the Game, 1999
  • Forgetting Sarah Marshall, 2008*
  • Fried Green Tomatoes, 1991
  • Get Him to the Greek, 2010
  • Harry Potter and the Chamber of Secrets, 2002
  • Harry Potter and the Deathly Hallows – Part 1, 2010
  • Harry Potter and the Deathly Hallows – Part 2, 2011
  • Harry Potter and the Goblet of Fire, 2005
  • Harry Potter and the Half-Blood Prince, 2009
  • Harry Potter and the Order of the Phoenix, 2007
  • Harry Potter and the Prisoner of Azkaban, 2004
  • Harry Potter and the Sorcerer’s Stone, 2001
  • He’s Just Not That Into You, 2009
  • Honey, 2003
  • Honey 2, 2011
  • I Think I Love My Wife, 2007
  • John Wick, 2014*
  • John Wick: Chapter 2, 2017*
  • John Wick: Chapter 3 – Parabellum, 2019*
  • Just Go With It, 2011*
  • Liar, Liar, 1997
  • Little Fockers, 2010
  • Looper, 2012
  • Lucy, 2014*
  • Major Payne, 1995
  • Marley & Me, 2008
  • Meet the Fockers, 2004
  • Meet the Parents, 2000
  • Mystery Men, 1999
  • Ocean’s Eleven, 2001
  • Ocean’s Twelve, 2004
  • The Other Guys, 2010
  • Robots, 2005
  • The Rock, 1996
  • Role Models, 2008
  • Shallow Hal, 2001
  • Shark Tale, 2004*
  • A Simple Favor, 2018
  • Sisters, 2015*
  • The Skulls II, 2002
  • The Skulls III, 2004
  • The Skulls, 2000
  • Stick It, 2006
  • Trainwreck, 2015*
  • Tremors, 1990*
  • Tremors 3: Back To Perfection, 2001
  • Tremors 4: The Legend Begins, 2004
  • Tremors 5: Bloodlines
  • Tremors 6: Cold Day In Hell, 2018
  • Tremors II, 1996
  • Unbreakable, 2000
  • What’s Love Got To Do With It, 1992
  • You Don’t Mess with the Zohan, 2008*
  • American Greed, Season 14
  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Shrink, Season 1
  • Snapped, 19-23
  • Southern Charm, Season 8, New Episode (Bravo)
  • Top Chef Last Chance Kitchen, Season 15-18
  • IndyCar – Mid-Ohio
  • Tour de France – Stage 1
  • Watch What Happens Live, Season 19, New Episode (Bravo)

Streaming July 2

  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Breeders Cup Challenge
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • IMSA  – CTMP
  • IndyCar – Mid-Ohio*
  • Pro Motocross – Red Bud
  • Tour de France – Stage 2*
  • WWE Money in the Bank*

Streaming July 3

  • Tour de France – Stage 2*
  • Indy Car – Mid-Ohio*
  • IMSA – Sportscar Grand Prix
  • MLB Sunday Leadoff – Kansas City Royals at Detroit Tigers*

Streaming July 4

  • Below Deck Mediterranean, Season 7, New Episode (Bravo)
  • Growing Up Chrisley, Season 3
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Macy’s 4th of July Fireworks Spectacular
  • Ukraine: Answering the Call (NBC)

Streaming July 5

  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Dateline: The Last Day, Season 1, New Episode (Peacock Original)* 
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Tour de France – Stage 4*
  • USA Softball vs. Australia*
  • USA Softball vs. Japan*

Streaming July 6

  • Amor Valiente, Season 1, New Episode (Telemundo)
  • America’s Got Talent, Season 17, New Episode (NBC)
  • Dancing With Myself, Season 1, New Episode (NBC)
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Tour de France – Stage 5*

Streaming July 7

  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Tour de France – Stage 6*
  • The Real Housewives of Beverly Hills, Season 12, New Episode (Bravo)
  • The Real Housewives of Dubai, Season 1, New Episode (Bravo)
  • The Real Housewives Ultimate Girls Trip S2, New Episode (Peacock Original)*  

Streaming July 8

  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Southern Charm, Season 8, New Episode (Bravo)
  • Trigger Point, Season 1, All Episodes (Peacock Original)* 
  • Tour de France – Stage 7*

Streaming July 9

  • American Century Championship
  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Tour de France – Stage 8*
  • Pro Motorcross 2022 – Southwick

Streaming July 10

  • American Century Championship
  • MLB Sunday Leadoff – Los Angeles Angels at Baltimore Orioles*
  • Tour de France – Stage 9*

Streaming July 11

  • Below Deck Mediterranean, Season 7, New Episode (Bravo)
  • Curious George, 2006
  • Days of Our Lives: Beyond Salem, Season 2, Episode 1 (Peacock Original)* 
  • Married to Medicine: Atlanta, Season 9, New Episode (Bravo)
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • The Real Housewives of Atlanta, Season 14, New Episode (Bravo)
  • The Real Housewives of Potomac, Season 6
  • The Shallows, 2016*
  • Watch What Happens Live, Season 19, New Episode (Bravo)
  • Who Do You Think You Are? Season 1, New Episode (NBC)

Streaming July 12

  • American Ninja Warrior, Season 14, New Episode (NBC)
  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Dateline: The Last Day, Season 1, New Episode (Peacock Original)*

  • Days of Our Lives: Beyond Salem, Season 2, Episode 2 (Peacock Original)* 
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Tour de France – Stage 10*

Streaming July 13

  • America’s Got Talent, Season 17, New Episode (NBC)
  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Dancing With Myself, Season 1, New Episode (NBC)
  • Days of Our Lives: Beyond Salem, Season 2, Episode 3 (Peacock Original)* 
  • Doom, 2005*
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Make Do & Mend, Season 2*
  • Tour de France – Stage 11*
  • Watch What Happens Live, Season 19, New Episode (Bravo)

Streaming July 14

  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Days of Our Lives: Beyond Salem, Season 2, Episode 4 (Peacock Original)* 
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • Hart to Heart, Season 2, Episodes 1-2, (Peacock Original)* 
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • The Open Championship – Round 1*
  • The Real Housewives of Beverly Hills, Season 12, New Episode (Bravo)
  • The Real Housewives of Dubai, Season 1, New Episode (Bravo)
  • The Real Housewives Ultimate Girls Trip S2, New Episode (Peacock Original)*  
  • Tour de France – Stage 12*
  • Watch What Happens Live, Season 19, New Episode (Bravo)

Streaming July 15

  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Days of Our Lives: Beyond Salem, Season 2, Episode 5 (Peacock Original)* 
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Nash Bridges, 2021
  • IndyCar – Streets of Toronto
  • Southern Charm, Season 8, New Episode (Bravo)
  • The Open Championship – Round 1*
  • Tour de France – Stage 13*
  • Watch What Happens Live, Season 19, New Episode (Bravo)
  • World Track & Field Championships*

Streaming July 16

  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • IMSA – Lime Rock
  • IMSA – Toronto – Porsche Carrera Cup
  • IndyCar – Streets of Toronto
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • MLB All-Star Futures Game*
  • Tour de France – Stage 14*
  • The Open Championship – Round 3
  • World Track & Field Championships

Streaming July 17

  • IndyCar – Streets of Toronto
  • MLB Sunday Leadoff – Kansas City Royals at Toronto Blue Jays*
  • The Open Championship – Final Round
  • Tour de France – Stage 15*
  • World Track & Field Championships

Streaming July 18

  • Below Deck Mediterranean, Season 7, New Episode (Bravo)
  • El Señor de los Cielos, Season 4-7
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Married to Medicine: Atlanta, Season 9, New Episode (Bravo)
  • The Real Housewives of Atlanta, Season 14, New Episode (Bravo)
  • Watch What Happens Live, Season 19, New Episode (Bravo)
  • Who Do You Think You Are? Season 1, New Episode (NBC)
  • World Track & Field Championships

Streaming July 19

  • American Ninja Warrior, Season 14, New Episode (NBC)
  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Dateline: The Last Day, Season 1, New Episode (Peacock Original)* 
  • Exhumed, Season 2, All Episodes (Oygen)
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Love Island, Season 4, New Episode (Peacock Original)* 
  • Snapped, Season 31, New Episode (Oxygen)
  • Tour de France – Stage 16*
  • Watch What Happens Live, Season 19, New Episode (Bravo)
  • World Track & Field Championships

Streaming July 20

  • America’s Got Talent, Season 17, New Episode (NBC)
  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Dancing With Myself, Season 1, New Episode (NBC)
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Love Island, Season 4, New Episode (Peacock Original)* 
  • Tour de France – Stage 17*
  • Watch What Happens Live, Season 19, New Episode (Bravo)
  • World Track & Field Championships

Streaming July 21

  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • Hart to Heart, Season 2, Episodes 3-4, (Peacock Original)* 
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Love Island, Season 4, New Episode (Peacock Original)* 
  • The Real Housewives of Beverly Hills, Season 12, New Episode (Bravo)
  • The Real Housewives of Dubai, Season 1, New Episode (Bravo)
  • The Real Housewives Ultimate Girls Trip S2, New Episode (Peacock Original)*  
  • Tour de France – Stage 18*
  • Watch What Happens Live, Season 19, New Episode (Bravo)
  • World Track & Field Championships

Streaming July 22

  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • IndyCar – Iowa*
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Love Island, Season 4, New Episode (Peacock Original)* 
  • Southern Charm, Season 8, New Episode (Bravo)
  • Tour de France – Stage 19*
  • Watch What Happens Live, Season 19, New Episode (Bravo)
  • World Track & Field Championships

Streaming July 23

  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • IndyCar – Iowa*
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Love Island, Season 4, New Episode (Peacock Original)* 
  • The Senior Open Championship
  • Tour de France – Stage 20*
  • World Track & Field Championships

Streaming July 24

  • IndyCar — Iowa
  • Love Island, Season 4, New Episode (Peacock Original)* 
  • MLB Sunday Leadoff – Chicago Cubs at Philadelphia Phillies*
  • The Senior Open Championship
  • Tour de France – Stage 21*
  • Tour de France Femmes – Stage 1
  • World Track & Field Championships

Streaming July 25

  • Below Deck Mediterranean, Season 7, New Episode (Bravo)
  • Married to Medicine: Atlanta, Season 9, New Episode (Bravo)
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • The Real Housewives of Atlanta, Season 14, New Episode (Bravo)
  • Tour de France Femmes – Stage 2
  • Watch What Happens Live, Season 19, New Episode (Bravo)
  • Who Do You Think You Are? Season 1, New Episode (NBC)

Streaming July 26

  • American Ninja Warrior, Season 14, New Episode (NBC)
  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Love Island, Season 4, New Episode (Peacock Original)* 
  • Snapped, Season 31, New Episode (Oxygen)
  • Tour de France Femmes – Stage 3
  • U.S. Swimming National Championships – Day 1
  • Watch What Happens Live, Season 19, New Episode (Bravo)

Streaming July 27

  • America’s Got Talent, Season 17, New Episode (NBC)
  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Love Island, Season 4, New Episode (Peacock Original)* 
  • Tour de France Femmes – Stage 4
  • U.S. Swimming National Championships – Day 2
  • Watch What Happens Live, Season 19, New Episode (Bravo)

Streaming July 28

  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • Hart to Heart, Season 2, Episodes 5-6, (Peacock Original)* 
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Love Island, Season 4, New Episode (Peacock Original)* 
  • The Real Housewives of Beverly Hills, Season 12, New Episode (Bravo)
  • The Real Housewives of Dubai, Season 1, New Episode (Bravo)
  • The Resort, Season 1, Episodes 1-3 (Peacock Original)*
  • Tour de France Femmes – Stage 5
  • U.S. Swimming National Championships – Day 3
  • Watch What Happens Live, Season 19, New Episode (Bravo)

Streaming July 29

  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Love Island, Season 4, New Episode (Peacock Original)* 
  • IndyCar – Indianapolis
  • Southern Charm, Season 8, New Episode (Bravo)
  • Tour de France Femmes – Stage 6
  • Watch What Happens Live, Season 19, New Episode (Bravo)

Streaming July 30

  • Amor Valiente, Season 1, New Episode (Telemundo)
  • Hasta Que La Plata Nos Separe, Season 1, New Episode (Telemundo)
  • La Casa de los Famosos, Season 2, New Episode (Telemundo)
  • Love Island, Season 4, New Episode (Peacock Original)* 
  • NASCAR Xfinity Series Race – Indianapolis
  • Nitro Rallycross – Sweden
  • IndyCar — Indianapolis
  • Tour de France Femmes – Stage 7
  • WWE SummerSlam*

Streaming July 31

  • Love Island, Season 4, New Episode (Peacock Original)* 
  • Nitro Rallycross – Sweden
  • MLB Sunday Leadoff – Detroit Tigers at Toronto Blue Jays*
  • Tour de France Femmes – Stage 8
  • US Classic Gymnastics – Men’s

That’s everything coming to Peacock throughout the month of July 2022. We’ll be back next month with all of the latest movies and shows.

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Jacob started covering video games and technology in college as a hobby, but it quickly became clear to him that this was what he wanted to do for a living. He currently resides in New York writing for BGR. His previously published work can be found on TechHive, VentureBeat and Game Rant.

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A fan-favorite Netflix reality show just got renewed for seasons 6 and 7

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A fan-favorite Netflix reality show just got renewed for seasons 6 and 7

Most Netflix original shows tend to get the ax from the streamer around Seasons 3 or, in rare cases, a fourth season of the series. But not when it comes to the glamorous real estate ladies of Selling Sunset, the guilty pleasure Netflix show that just got picked up by the streamer for two more seasons (#s 6 and 7).

Name almost any Netflix show you can think of, and chances are its run has ended at least two and probably three seasons behind where Selling Sunset will be once Season 7 rolls around. And not only that — this dishy, buzz-worthy show that celebrates the wealth porn of the 1 percenters has already inspired two spinoffs (Selling Tampa, and Selling the O.C.).

Will there be a season 6 of Selling Sunset?

Netflix announced on Thursday that its Emmy-nominated docusoap will have at least two more seasons. And not only that — production is set to get underway later this summer.

The show takes place amid the high-end world of LA real estate, and it follows the successful female realtors who work together at The Oppenheim Group, an agency where the competition is cutthroat and the gorgeous surroundings of the Hollywood Hills and Sunset Strip belie the hard work required to “make it.”

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Moreover, Netflix announced the Selling Sunset news in tandem with the announcement of a slew of other new show details. They include premiere dates for several real estate-themed series coming to the streamer, like:

  • How to Build a Sex Room (Debuts July 8)
  • Dream Home Makeover Season 3 (Debuts July 27)
  • Instant Dream Home (Debuts August 10)
  • Selling the O.C. (Debuts August 24)
  • Designing Miami (Coming September 21)
  • Buying Beverly Hills (Fall debut TBA)
  • Buy My House (Fall debut TBA)

“Luxe real estate. Major drama.”

For those who haven’t checked it out yet, Netflix promises that Selling Sunset viewers will get episode after episode of “luxe real estate” and “major drama.”

The show follows a group of the city’s most successful female realtors who all work under the same roof, who “work hard and play harder, as they compete with the cutthroat LA market and each other. These ladies will do what it takes to make it to the top of their game, all while trying to keep their personal lives intact.”

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Mary Fitzgerald, shown in episode 2 of Netflix’s “Selling Sunset,” Season 5. Image source: Netflix

Season 5 of Selling Sunset currently has a percent 100 percent critics score on Rotten Tomatoes. All 11 episodes of the latest season are streaming now on Netflix. And that total includes the season’s reunion episode, for which host Tan France (from Netflix’s Queer Eye) leads a discussion with the cast about the show and their lives today.


More Netflix coverage: For more Netflix news, check out the latest new Netflix movies and series to watch.

Andy Meek profile photo

Andy Meek is a reporter based in Memphis who has covered media, entertainment, and culture for over 20 years. His work has appeared in outlets including The Guardian, Forbes, and The Financial Times, and he’s written for BGR since 2015. Andy’s coverage includes technology and entertainment, and he has a particular interest in all things streaming. Over the years, he’s interviewed legendary figures in entertainment and tech that range from Stan Lee to John McAfee, Peter Thiel, and Reed Hastings.

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