By sequencing biological samples collected by 118 passengers passing through the Angola International Airport, an international research team led by scientists from Durban KwaZulu-Natal University discovered SARS-CoV- in three tourists from Tanzania. Of the new variants of the coronavirus, 2 of them are the most serious. Mutations have been discovered. The Tanzania variant actually has 34 mutations, 13 of which are located on the S protein.
At an airport in Angola Africa, Three travelers from Tanzania One kind”Super variant” of Coronavirus SARS-CoV-2, This The biggest change in history Since i tree stump new Pandemic pathogen.This Variations of Tanzania Its characteristics are actually 34 mutations, Of which 13 are in Protein S Ø spike, The “biological selection” used by the virus to bind ACE-2 receptor Human cell, break the cell wall, pour outViral RNA Inside and start the process copy, Which is the basis of infection (called Coronavirus disease). For comparison, the Brazilian variant P.1 (variation of interest 202101/02-20J/501Y.V3) has a total of 18 mutations, of which 10 are on protein S, and the English variant B.1.1.7 (variation of interest) There are 17 on 202012/01-VOC-202012/01), of which there are 8 on S.
Discover and describe variants”Super mutation“The Tanzanian people are a large international research team led by scientists from the University of KwaZulu-Natal University of KwaZulu-Natal, Durban, South Africa, Research Innovation and Sequencing Platform (KRISP). University of Cape Town, the university’s colleagues work closely with Oxford (UK), the Osvaldo Cruz Foundation (FioCruz) in Rio de Janeiro (Brazil), the African Center for Disease Control and Prevention (African Center for Disease Control and Prevention) And other research centers.Scientists coordinated by Professor Richard J. Lessells of the University of South Africa’s “Nelson Mandela” School of Medicine after the discovery of the Tanzanian variant Sequelae As many as 118 biological sample links TamponCollected by passengers transiting at Angola International Airport between June 2020 and February 2021. As shown in the picture, the strain was found in three travelers from Tanzania in mid-February. Their health status is unknown.
Come Assigned to Forbes Written by Professor William A. Haseltine, a former lecturer of the famous Harvard Medical School, Interest variants (VOI-Variant of Interest) is not only related to a large number of mutations, but also related to the location of the mutation. Among other things, “Immune escape” E484K It is also found in variants in South Africa and Brazil; genetic modification guarantees the virus to a certain extent Resistance i Neutralizing antibodyAnd the previous ones Natural infection (So catalyzed Reinfection) Byo Coronavirus disease vaccine. Another notable mutation in the Spike protein is P681H. This change occurs near the cleavage site between the S1 and S2 Spike subproteins.We and others speculate that this mutation will increase Transmissibility Increased the efficiency of spike precursor protein S, which is a requirement for infectivity”, Emphasis on Professor Haseltine.Other non-protein S mutations of interest to scientists include process changes orf1ab Related to replication, one involves the “shell” protein (E) of the virus, and the other involves Nucleocapsid protein (N).
One of the most disturbing aspects of this new Tanzanian variant is the context in which it emerged.Former President of Tanzania John MagfleyHe died in a mysterious environment on March 17 this year. He has repeatedly announced that he can Prayer, herbs and herbal tea, Without the need to adopt strict anti-infection measures like other parts of the world. Since April last year, because the virus “has disappeared,” no official data on the local epidemic has been released.Tanzania is a country with a population of 58 million (actually the population of Italy), and it officially started counting today 509 infections and 21 deaths From the beginning Pandemic, And there is almost no situation for a year.If we think the neighbor KenyaSo far, the country has recorded 153,000 infections and 2,540 deaths, which at least partly explains the true situation in Tanzania.Believe that the former president himself has passed away Coronavirus disease, Despite the mention of a cardiac event in the official communication (he is 61 years old).
According to scholars, the lack of anti-infective measures has become rich soil The new mutant variant used to develop SARS-CoV-2, as found in three travelers from Tanzania. Details of the study”A new and interesting variant of SARS-CoV-2 detected by Africa Travel Monitoring, with multiple peak mutations“It has been uploaded to the MedrXiv online database and awaits publication in scientific journals.