Through a complex molecular epidemiological investigation, the study was able to reconstruct the “family tree” of the SARS-CoV-2 coronavirus. A research team led by scientists from Temple University in Philadelphia determined that the ancestor of the pathogen, proCoV2-, has been Popular in China in October 2019. When Wuhan first broke out, it had already spread around the world.
As of May 6, 2021 (Thursday), according to “Interactive mapJohns Hopkins University Coronavirus SARS-CoV-2 Globally, it has infected more than 155 million people and killed 3.2 million people ( Italy A total of 4 million infections and 122,000 deaths were recorded). This health, social and economic disaster is not caused by the same virus all the time, but by multiple viruses. Different pedigrees/variants From Original strain,finished Species leap From animals to people, the so-called Spillover.Scientists discovered that this Progenitor cells of SARS-CoV-2, Called proCoV2, Along with some variants since then October 2019, Before confirming First genome Called in China Wuhan 1.
An international research team led by scientists from the Institute of Genomics and Evolutionary Medicine at Temple University in Philadelphia described the role of proCoV2. The team worked closely with colleagues from the Center for Excellence in Genomic Medicine and Research at King Abdulaziz University in Jeddah ( Saudi Arabia). Scientists coordinated by Professor Sudhir Kumar, Professor of Biology Department of American University, use a method called “Mutation sequence analysis“,is widely used in Cancer research.It is based on Mutant as well as Pair mutation Appear together, the data thanks to it can be returned to Evolutionary history By rebuilding the virus’Family Tree“Then determine its ancestors.
Since the first case of SARS-CoV-2 infection was confirmed as Wuhan-1 strain in December 2019, “more than one million SARS-CoV-2 genomes have been sequenced worldwide, revealing that the coronavirus is mutating. , Despite the slow progress, there are 25 mutations per genome each year,” Press release. This means that the monthly mutation rate of the virus is about 2 mutations. “Lots of Emerging variants, Including the United Kingdom (B.1.1.7), South Africa (B.1.351), South America (P.1) and now India (B.1.617), not only replaced the previous “their respective regions, but because of their Has the potential to evade today’s vaccines and therapies while still threatening global health,” Professor Kumar and colleagues pointed out.
Scientists pointed out that the first thing happened in Wuhan Overspread This virus, but it has been circulating around the world for some time (in Italy since December 2019, and then “exploded” in February 2020). “We discovered the genetic fingerprint of progenitor cells in January 2020, and subsequently discovered the gene in multiple coronavirus infections in China and the United States. Months before and after the first COVID-19 case was reported in China, the ancestors spread worldwide , He has announced Study co-author Sergei LK Pond (Sergei LK Pond).
When the first case was found in China, strains with at least three genetic differences (mutations) had spread widely. proCoV2. According to molecular epidemiological investigation, it can be determined that the progenitor cell appeared in China, but we don’t know who it is.Patient Zero“- the first to be infected by the coronavirus-because the first confirmed genome has been very different from the original proCoV2. As experts explained, the Asian coronavirus strain “has established a complete Pandemic“But the variants that have appeared in other parts of the world are infecting Asia. Apart from not knowing the number of patients, we don’t even know which one is Tank type, This is the intermediate host, which makes it possible for viruses that can indeed be born in animals to jump from animal species to human species Horseshoe bat. The details of the study”An evolutionary diagram of the progenitor cell SARS-CoV-2 and its dominant branch in the COVID-19 pandemic“Published in the professional scientific journal “Molecular Biology and Evolution”.