A research team at the National University of Singapore (NUS) has developed a revolutionary blood test called ExoSCOPE that can determine whether targeted cancer treatments are effective. Unlike the weeks required by other techniques, the response can be obtained only 24 hours after the start of treatment. This is how it works.
Through a simple Blood sample It will be possible to understand if Targeted therapy Against this cancer Working, within 24 hours of startup treatmentThis is very valuable information that can help doctors recalibrate the treatment, thereby increasing the patient’s chances of survival, everything is in Very fast time it is at lower the costThanks to this innovative blood test, in fact, it is possible to circumvent (or at least limit) other technologies that require long time and huge cost, such as observation Tumor volume And invasive sampling Biopsy.
The pioneering blood test was developed by a research team led by scientists from the Institute of Health Innovation and Technology, National University of Singapore (NUS), who worked closely with colleagues from the Department of Biomedical Engineering, Department of Surgery, and Institute of Science, Technology and Research of Singapore Department of Molecular and Cell Biology.Scientists coordinated by Professor Shao Huilin decided to call this technique Outside mirror, An acronym for “small molecule chemical occupancy and protein expression monitoring of extracellular vesicles”.In short, the test looks for Extracellular vesicles (EV) secreted cancer cell And circulate in the blood, its characteristics can indicate whether the drug is effective Solid tumor.
“Traditional surgery such as tumor imaging is not only expensive, but also time-consuming. For these methods, the treatment effect can only be determined after a few weeks. With ExoSCOPE, we can directly measure the results of drug efficacy within 24 hours after starting treatment. This will greatly reduce monitoring. The time and cost of cancer treatment,” he said in a statement. Press release Professor Shao. “This method requires only a small amount of blood for analysis, and each test can be completed in less than an hour. Therefore, it is less invasive but more informative. In this way, clinicians can China monitors patients’ response to treatment more regularly and makes timely personalized adjustments to improve results,” the scientist added.
But how exactly does ExoSCOPE work? As shown in the picture, it looks for EVs, small membrane vesicles that are not visible under a light microscope (the researchers explain that it is a hundred times smaller than the diameter of a human hair). When targeted anti-cancer drugs work, Active principle Invade diseased cells and reduce tumor growth; cells respond to this process by releasing drug-containing vesicles. “The ExoSCOPE sensor contains millions of Golden Nano Anelli Capture extracellular vesicles and amplify drug-induced signals Strong light signal. These light signals are then processed to provide readings indicating the effectiveness of the drug,” said study co-author Zhang Yan. The effectiveness and accuracy of the technology have been Clinical research 106 patients have Lung cancer, The accuracy was found to be 95% (after comparison with tumor volume imaging). Scientists hope that this technology can be applied not only to various forms of cancer, but also to many other diseases. Research detailsThe drug occupancy rate of extracellular vesicles can be monitored in real time for targeted cancer therapy“Published in the authoritative scientific journal “Nature Nanotechnology”.