The solution hypothesized by the German researchers first describes the possible immune response that may cause blood clots after inoculation with AstraZeneca: “A half dose can reduce side effects and is unlikely to cause these adverse events.”
The solution to rare thrombosis after Covid vaccination may be Halved. German researchers asked to test another disease state. They first described the immune response that may cause blood clots after being vaccinated with AstraZeneca. The researchers pointed out that in phase 3 clinical trials, the same vaccine was mistakenly administered to some volunteers in smaller doses. The researchers pointed out that lower-than-standard doses usually showed fewer side effects. “Maybe -Argument science – Lower doses are unlikely to cause severe inflammation, which will also increase PF4 antibodies“.
A research team led by Andreas Greinacher, a coagulation expert at Greifswald University, recently published in New England Journal of Medicine A series of case reports showed that thrombotic events related to low platelet counts were observed after the first dose of AstraZeneca. In their article, they speculate that adenovirus is used as a carrier of genetic material to produce Spike protein in the virus in the cell. Will break and release DNA.For example, heparin, a drug known to have a rare reaction (heparin-induced thrombocytopenia), whose immune system produces antibodies against a complex composed of heparin and a protein Platelet factor 4 (PF4), It is also possible that DNA that forms a multi-molecular complex with PF4 induces the production of antibodies that can selectively bind to PF4. This binding activates the platelets, which then begin to bind together, forming dangerous clots in the blood. “Immune response to extracellular DNA -Observed Greinancher- It is part of the ancient immune defense system triggered by a serious infection or injury, and free DNA itself can send a signal to the human body to increase blood clotting“.
Understanding the mechanisms that cause these coagulation reactions is critical to understanding whether there are other anti-Covid vaccines Based on adenovirusFor example, products produced by Johnson & Johnson (currently suspended by the Food and Drug Administration (FDA) in the United States due to reports of six thromboembolic events, and also used in Europe), may lead to similar incidents. Other countries have approved at least two other vaccines that use adenovirus as a viral vector, namely Russian Sputnik and Chinese Cansino, although none of these side effects have been reported.
According to Greinacher, a molecular biologist at the University of Frankfurt, and his collaborator Rolf Marschalek, Half-dose administrationAs happened by accident in Astrazeneca clinical trials, it can reduce side effects and is unlikely to cause severe inflammation. This inflammation also increases antibodies against PF4. “unexpectedly -Marschalek said- People who received lower doses received slightly more protection, probably because high levels of inflammation can actually prevent antibody formation“.”Part of the problem -Added Greinancher- Maybe they overdose“For vaccines.
However, the most common side effects occur less frequently after taking a half dose This does not mean that this situation will occur in a very rare adverse event, The scientist warned. However, if the intuition is correct, then one of the most important weapons in disguise seems to have suffered a terrible blow. This may be the good news in disguise: each standard dose can be vaccinated twice as many people with fewer side effects.