The Alpha (previously English) and Beta (previously South African) variants of the SARS-CoV-2 coronavirus may reduce the effectiveness of Pfizer BioNTech’s Covid vaccine. A new study proves this, which compares the infection rate of vaccinated and unvaccinated: in the former, mutation dominates according to a defined time window.
This Variations of concern (VOC) Del Coronavirus SARS-CoV-2 The World Health Organization classifies it as (WHO) When they appear to be able to present Pandemic pathogen more Spreadable, Provocation this is Elusivo Against this Neutralizing antibody, Are all caused by the previous one Natural infection (Risk of catalytic reinfection) than derived from vaccinationAlthough several studies have shown that vaccines that have been approved for emergency use are effective against the main variants in circulation, one New survey However, Israel indicated that the infections recorded among the vaccinated persons were mainly caused by these mutant strains, which indicates that they have better “breakthrough” signs of immune defenses.
Leading the new research is a research team led by scientists from the “George S. Wise” School of Life Sciences at Tel Aviv University who work closely with colleagues from the Clalit Institute. Gertner at Chaim Sheba Medical Center, Health Sciences at Ben Gurion University of the Negev, Tel Aviv University, Clinical Virology Laboratory at Soroka University Medical Center, and other Israeli research institutes.Scientists coordinated by Professor Adi Stern, lecturer at the Shmunnis School of Biomedicine and Cancer Research, Tel Aviv University, are comparing Infection rate Between vaccinated people A kind Oh Two doses of Coronavirus disease vaccine of Pfizer-BioNTech Those who have not been vaccinated are part of Clalit Health Service, which is the largest health organization in the Middle East, providing insurance for 4.7 million people, accounting for 53% of the Israeli population.
Between January 3 and March 7, 2021, scientists detected approximately 3,500 infections Among the partially or fully vaccinated population, it is from the coronavirus SARS-CoV-2, but only for 433 (247 people received one dose of vaccine, 149 people received two doses of vaccine) data from Gene Sequencing, Which is necessary to determine the mutation that caused the infection. Every infected vaccine is matched with an unvaccinated infected person (Control group), test positive on similar dates and have similar demographic characteristics (such as age, gender, race, and place of residence) to minimize the impact of differential exposure.Analysis of the sequence showed that the infection Alpha variant (ex English B.1.1.7) In partially immunized people, it is twice as high as infected but not vaccinated, and there is no difference between fully vaccinated and unvaccinated. From the analysis of the genetic sequence, the scientists also showed that those who received a positive result (at least 7 days after the second vaccination) were much more affected. Beta (Formerly South Africa B.1.351), but it should be borne in mind that these infections were detected before the 14th day after the second injection, which triggered full vaccination coverage at that time.
The results show that Pfizer-BioNTech’s vaccine is less effective for both Alpha and Beta variants in certain time windows, so Professor Stern and colleagues emphasized the importance of continuing research track Strictly control the variants of SARS-CoV-2 and continue quickly Vaccination campaign To avoid the spread of new bloodlines. Research detailsEvidence for increased breakthrough rate of SARS-CoV-2 related variants in individuals vaccinated with BNT162b2-mRNA“Published in “Natural Medicine” magazine.