A research team from Imperial College London showed that the active ingredients contained in psilocybin combined with psychotherapy have the same antidepressant effect as ordinary antidepressants. One of the advantages lies in the reduced side effects. However, for all confirmed cases, more in-depth research must be conducted.
This Active principle Contained in the so-called “Hallucinogenic mushrooms“, if and Psychotherapy Can target Frustrated Guaranteed by the city government Antidepressants.This is about Nature of treatment of psilocibina, An alkaloid (tryptamine) illusory It is present in certain mushrooms, such as Chlorothrinopsis and Panaeolus in high concentrations.In Italy and most of the world, this is a Illegal drugsHowever, some small experimental studies have begun to prove its effectiveness against certain mental illnesses, especially anxiety And depression, although always under close medical supervision.
Determine that psilocybin can have antidepressant effects like the most common drugs-gli Selective serotonin reuptake inhibitor (SSRI)-A research team led by British scientists from the Department of Brain Science at Imperial College London. Researchers led by Professor Robin Carhart-Harris, lecturer at the Center for Psychedelic Research, University of London, came to their conclusions after studying patients with the following diseases. Major depression Persistent (moderate to severe). The researchers divided 59 patients into two groups (one of 30 and 29): The first group, the psilocybin group, received two doses of 25 mg psilocybin, with an interval of 3 weeks and an interval of 6 weeks. Daily placebo, And the second control group (control group) was given cilobibine orally for 6 weeks every 3 weeks, and received two doses of 1 mg psilocybin. Escitalopram, The active ingredients present in the main antidepressants. All patients were followed up. Psychotherapy.
The research is on Double blind, It is also randomized and controlled, so use “Gold standard“Scientific research. In short, the study authors did not know which patients were given higher doses of sesquimycin or antidepressants (the patients did not even know what they were taking). Six weeks after the trial began, the researchers Participants were provided with the “Quick Questionnaire for Depressive Symptoms-Self-Report” questionnaire (QIDS-SR-16), which was used to determine their depressive status by scoring. Data analysis showed that psilocybin has the same antidepressant effect as the drug , Thereby improving Mental Health Of patients. In fact, those who received psilocybin improved slightly, but according to scholars, this is not the case. Statistically significant.
It should be remembered that antidepressants usually show their effects a few weeks after starting antidepressants. treatmentTherefore, the researchers believe that if they submit the questionnaire after six weeks, the treatment effect of the escitalopram group may be more obvious.One of the most interesting aspects of the research is side effect; It is well known that antidepressants may produce a series of adverse reactions, including dizzinessfatigue insomnia, Weight gaine Loss of libido. Moreover, in some cases, they are not effective. It is for such patients that alternative solutions are being studied, such as psilocybin-based solutions. Five patients in the escitalopram group either did not continue treatment or had to reduce their treatment. dose Due to side effects, the group receiving psilocybin continued to receive treatment until their normal term was normal.The only side effect is headache After applying the active ingredient.
Professor Carhart-Harris and colleagues Emphasize the importance Psychotherapy and medical treatement, Especially in light of Hallucinogenic effect Triggered by psilocybin, it must not be used as a “self-therapy”. Although the results are encouraging, due to the small number of patients and other limitations, there is still a need for more in-depth research to understand the true antidepressant effects of “hallucinogenic mushrooms”. The details of the study”Trial of Xiloxibine and Ecitalopram in the Treatment of Depression“Published in the authoritative scientific journal “New England Journal of Medicine.”