An international research team led by scientists at Brigham and Women’s Hospital in Boston has created a revolutionary 3D model of the human lung that can be used to test and discover new drugs for multiple respiratory diseases, including COVID-19 and lung cancer.
Revolutionary products made in the laboratory 3D model copy Human lung tissue, A kind of”Lung sliceWhich can let you test drug And verify certain evolutions Morbid Affect the respiratory system.Using this model can speed up the time to discover and select new models Positive principle May be effective, and reduce use Animal model In the experiment.This is fighting against things like pneumonia,asthma,influenza, Chronic obstructive pulmonary disease, lung tumor and also Coronavirus disease,by Coronavirus SARS-CoV-2.It’s no accident that the scientists who created the 3D model of the “chip on the lung” are already preparing experiments to study Variants Pandemic pathogens.
This new lung model was developed by an international research team led by scientists at Harvard University’s Brigham and Women’s Hospital, which worked closely with colleagues from the Nano Biomaterials and Regenerative Medicine Research Center of Taiyuan University of Technology, Southeast University Bioscience Department of Medical Engineering, Monterrey Institute of Technology and Higher Education (Mexico), Department of Chemistry, Materials and Chemical Engineering of Politecnico di Milano, University of Milan, Italy, many other institutes. Scientists led by Yu Shrike Zhang, professor of bioengineering in the Department of Medical Engineering at Massachusetts Hospital, developed this technology to faithfully reflect the characteristics of the human lung.Specifically, this part Distal organs/alveoli, Where there are tiny pockets (Alveoli) In which the harvest was collected and exchangedoxygen While breathing
So far, experimental lung models developed in the laboratory tend to have two-dimensional structures.The new technology is based on Hydrogels Based on porous three-dimensional (3D) Methacryloyl gelatin (GelMA) has a unique “inverse opal” structure, linked to a device on a chip that allows an interface Gas liquid And periodic breathing exercises, which are characteristic of lung breathing. Human lung cells grow inside the structure and occupy 3D space within a few days, effectively replicating the structure of the organ. Therefore, it is a “workbench” that can revolutionize pharmacy and disease research. “We think this is a real innovation. This is the first in vitro model capable of replicating the human lower lung, which can be used to test many biological mechanisms and therapeutic agents, including antiviral drugs for COVID-19 research. Press release.
Scientists say that with such a model, it is possible to verify me Anti-Covid drugs (E.g. remdesivir) take action Virus replication, It may be the best choice to treat patients. The speech can be extended to a variety of other respiratory diseases, from influenza to lung cancer.For example, in an experiment, they let a 3D model invade Cigarette smoke They simulated the mechanical action of breathing; because of this process, they were able to observe in detail the cell damage caused by a wide range of vices. Scientists emphasize that this is still an “immature” technology-it can be said that only two types of lung cells are involved in the existing more than 40 lung cells-so it must be further refined and tested.However, once it is ready, it will be able to deal with all the pathologies that cause disease more effectivelyPulmonary insufficiencyIt is one of the leading causes of death in the world. The details of the study”Reverse engineered human alveolar lung slice model“Published in the scientific journal PNAS.